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  • 學生 教工 校友 考生 訪客

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    顧問、名譽、兼職教授

    陳凱先

    陳凱先

     

    陳凱先,藥物化學家 ,1945828日生于重慶,籍貫江蘇南京。1967年畢業于復旦大學。1982年和1985年先后在中國科學院上海藥物研究所獲碩士和博士學位。中國科學院上海藥物研究所研究員、學術委員會主任,“973”項目首席科學家,同濟大學顧問教授。曾任上海藥物研究所所長。1999年當選為中國科學院院士。

    主要從事藥物化學和創新藥物研究,是我國該領域的學術帶頭人之一。進行藥物構-效關系和生物活性小分子化合物結構預測的研究。與研究組同事一起提出和改進了多種計算機輔助藥物設計的方法和技術,包括分子疏水作用力場和藥物構象研究的方法、藥效基團搜尋方法、利用計算機構建具有結構多樣性的分子庫和模擬篩選的方法等,并應用于多種藥物與生物大分子相互作用的分子模擬和理論研究。開展了基于藥物與受體三維結構的藥物設計研究,其中一些受體三維結構模型和新藥的分子設計得到了實驗的驗證。近年來和同事一起針對20余個重要的藥理作用的靶標分子,進行計算機模擬篩選和初步的藥理試驗驗證,發現有苗頭的酪氨酸激酶抑制劑、高活性的PPARg激動劑,小分子b分泌酶抑制劑等先導化合物。曾獲法國尼納舒可倫獎等獎勵。


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